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    Host Defense Information

    Stamets 7- The Functional Food Multiple

    Stamets 7- The Functional Food Multiple

    The Functional Food Multiple Formula Designed for Daily Maintenance*

    On a daily basis, we come into contact with over 2000 carcinogenic compounds. Just some of these include:

    • Benzenes from solvents, paints, and dry cleaning
    • Formaldehyde from laminated wood, particle board and some foam insulations
    • Nitrosamines from cigarette smoke
    • Aromatic hydrocarbons from petro-chemicals, paints and various fuels and their exhausts
    • Xeno-estrogens from PCB’s (Polychlorinated Biphenyl, parabens, phthalates, BPA (Bisphenol A)

    Increasingly, people turn to a core group of supplements that typically includes a multivitamin, a probiotic and a DHA/EPA essential fatty acid. This regimen offers some daily support, but what can you take daily for core immunity, for cellular and foundational support throughout the year, to shield from everyday environmental stressors?

    Stamets 7® is the multifaceted, whole-food answer for a daily multiple supporting Immunity for Life!* A balanced formula of seven well-researched species, Stamets 7® offers functional food nutrition on a cellular level to complete your daily regimen.

    Combining mushrooms provides the following benefits:

    • Increased Natural Killer Cell and macrophage numbers and their activity when compared to same sized serving of single species
    • Full range of macro- and micronutrients from the mushroomforming mycelium and growth medium
    • Whole food nutrition, readily digestible and absorbable by the body
    • Novel compounds
    • Greater range of nutrients to support the major systems of the body, when compared to taking a single species

    Stamets 7 Take Away Points

    • A functional food multiple formula that fills the gap in a Core Daily Supplement Regimen
    • Support for daily metabolic and environmental assaults*
    • Full range of macro-nutrients including readily digestible and absorbable proteins and polysaccharides
    • Mushrooms in concert together offer greater range of nutrients to support major bodily systems*

    Why Take A Beneficial Mushroom For Health?

    Why Take A Beneficial Mushroom For Health?

    we share more DNA with mushrooms than with plants

    Because of this connection, we can easily utilize compounds from beneficial mushrooms for total body support.*

    mushrooms support our natural immunity

    Plus they give nutrients to support every body system, from brain and nerves to energy to skin cells.*

    mushrooms are the original superfood

    Used cross-culturally for thousands of years, ancient people utilized beneficial mushrooms for health and as sources of food.

    Modern science continues to recognize the array of health-supporting compounds found in mushrooms.*

    mushrooms are functional food, can be used everyday and have a full-spectrum of constituents which:

    • support a multitude of body systems*
    • augment the body’s immune system*
    • provide building blocks for our systems on a cellular level*
    • contain enzymes to support digestion and assimilation of nutrients*
    • contain polysaccharides to increase the activity & effectiveness of natural killer cells and macrophages*
    • neutralizes free radicals with antioxidant activity*
    • contain prebiotics and are food sources for probiotic microflora in the intestinal tract
    • support stress and fatigue reduction*
    • provide support for daily metabolic and environmental assaults*
    • offer a food source of nutrition that is readily digestible and absorbable*

    Glossary of Terms


    Arabinoxylane - A compound comprised of two sugars: arabinose and xylose, and derived from the conversion of rice bran via extracellular enzymes exuded from mycelium. Enhances immune response.

    Beta-Glucans - Polysaccharides found in mushroom cell walls, formed of sugar molecules arranged in specific patterns, and notable for immune modulation.

    Ergosterol - A biological precursor (provitamin) to vitamin D2, native to fungal cell membranes.

    Extracellular metabolites - Substances excreted from fungal mycelia into the growth medium. These compounds include enzymes, acids, sterols, antimicrobials, etc., whose functions range from digesting the substrate to protecting the organism from predators and competitors.

    Fruitbodies - The reproductive phase of the fungal organism that holds the spores for propagation. This form typically has a stem and cap.

    Functional Food - Food-based products containing additional health-promoting benefits beyond basic nutrition.

    Galactose - Simple sugar (monosaccharide) found in plants, fungi, and dairy products. Precursor or building block to complex compounds like glycoproteins and other glycoforms.

    Glucose - Simple sugar (monosaccharide) found in plants and fungi. Absorbed directly into the bloodstream during digestion, and used as primary metabolic fuel.

    Glycoproteins - Compounds consisting of carbohydrates (saccharides) and proteins. Immunologically important in cell-to-cell interactions, including white blood cell recognition. Glycoproteins also help bind together connective tissues.

    Inoculate - To introduce fungal mycelia into a new environment that contains the nutrients and other conditions necessary for expansion or growth (e.g. mycelia added to brown rice).

    Macro-nutrients - Proteins, fats and carbohydrates found within foods that provide energy to human bodily systems.

    Mannose - Simple sugar (monosaccharide) found in plants and fungi, and important in human metabolism. Precursor or building block to complex compounds like glycoproteins and other glycoforms.

    Micro-nutrients - Vitamins, minerals and trace elements which humans cannot produce, yet are required for various physiological functions. Other substances (typically complex molecules) such as antioxidants, phyto-chemicals, sterols, etc., also fit within the micronutrient classification.

    Mycelium - The vegetative, root-like part of a fungus, consisting of a mass of branching, thread-like hyphae. Typically found on/within the growth medium (wood, grain, organic matter).

    Mycology - The scientific study of fungi.

    Mycoattractants - Fungi used for attracting and controlling insects and arthropods, replacing toxic, chemical-based pesticides.

    Mycoremediation - The use of fungi to restore physically damaged or toxic ecosystems to a functional, balanced state.

    P-Value™ - An exponential scale devised by Paul Stamets for measuring the expansion or age of mycelium through successive inoculations. Indicates how close a mushroom strain is to its origin.

    Polysaccharides - Long, complex carbohydrate compounds. Important dietary elements for humans that provide source of energy.

    Primordia - A stage of the fungal life cycle at which the mycelial mat has developed adequately to support the reproductive stage of the organism and birth the fruitbody. Moreover, the primordial stage contains the constituents of both the mycelia and the fruitbody, as both stages are simultaneously present.

    Spores - Seed-like structure of fungal life cycle containing genetic material that is matured in the fruitbody and ejected into the environment to propagate the species.

    Substrate - Growth medium or food source. For Host Defense supplements, we use organic brown rice for mycelia and red alder wood chips for some fruitbodies.

    Triterpenoids - Large class of organic compounds that form the structural precursors to all steroids. Are major biosynthetic building blocks within nearly every living creature.

    Xylose - Simple sugar (monosaccharide) found in plants and fungi. Precursor or building block to complex compounds like glycoproteins and other glycoforms.

    For educational purposes only. © 2013 Paul E. Stamets and Fungi Perfecti, LLC, All rights reserved.

    Beta-Glucan Analysis and the Seven Pillars of Immunity


    Currently, there seems to be a lot of confusion about beta-glucans and their contribution to the beneficial properties of mushrooms. In order to shed more light on the subject, Paul Stamets has written a new article, "Beta-Glucan Analysis and the Seven Pillars of Immunity".

    Q: Why don’t you list beta-glucan content on your products?

    A: Because we want to be accurate. The testing methods used to determine beta-glucan content are highly inaccurate.

    Over the years, Fungi Perfecti LLC has spent thousands of dollars on product testing for beta-glucan content at various laboratories. The reported beta-glucan values from several independent laboratories vary greatly even though identical assays were performed. The most commonly employed assays for determination of beta-glucan content can only detect soluble beta-glucans; the insoluble beta-glucans remain undetected. Beta-glucans differ in their solubilities depending on their size, functionality, and interaction with other molecules. In agreement with other organic chemists specializing in beta-glucan analysis, we have concluded that the currently employed methods are unreliable! Deciding to place a percentage on our labels gives us sufficient pause, as we know each methodology and each laboratory would yield a different result. There is no standard, accepted,  validated methodology in the industry. This fact makes us reluctant to make any such claims on our product labels, and makes any purported beta glucan levels listed for any mushroom product dubious.

    Analytical laboratories have admitted that some mushroom companies use chitinase to convert otherwise water-insoluble sugars (chitin) into beta-glucans so their analyses falsely meet their desired marketing goal; a technique that simply embellishes the beta-glucan content in order to mislead the customer. Another trick some companies employ is to use beta-glucans isolated from yeast, such as Saccharomyces cerevisiae and list them as ‘mushroom beta-glucans’ on their product label—more than a bit of a stretch of logic, truth and reason. Yeasts are the simplest forms of fungi: many yeasts do not form mycelium and lack the cellular complexity of higher fungi, The other, non-beta-glucan constituents embedded into the cellular architecture of mushroom mycelium distinguishes the immunological activity of mushrooms from yeasts..

    Here at Fungi Perfecti, we are addressing this problem. Dr. Regan Nally, who directs our chemical analytical division, is leading this research effort by writing for publication an article for peer-reviewed journal exploring numerous inaccuracies in beta-glucan analyses.

    So I ask: what would you do? What is the scientifically accurate and ethical response? If you had one identical product tested at several laboratories but whose results ranged from Non Detectable to 40%, which would you put on the label? This is why Fungi Perfecti is different: if we are not confident in the scientific method being used by the industry, we refuse to pass on what we consider to be misinformation.

    The immune system is activated multifactorially by many components in mushrooms. Beta-glucans are just one. Other constituents include but are not limited to alpha-glucans, ergothioneines, antioxidants, anti-inflammatory sterols, lipids, glycosides, and mycoflavonoids—many of which work synergistically to optimize health. The efficacy of a multi-constituent approach has been positively confirmed in the scientific literature. Many of these active ingredients are not water soluble, meaning that they are not pulled out by hot water extraction. The inclusion of these beneficial co-ingredients enhances their protective effects. These constellations of complementary constituents are the foundation of our Host Defense mushroom product line.

    For educational purposes only. © 2013 Paul E. Stamets and Fungi Perfecti, LLC, All rights reserved.