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Host Defense Mushrooms - A product of Fungi Perfect. Host Defense Mushrooms Logo Black
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Host Defense Mushrooms

A Product of Fungi Perfecti

Building a Bridge Between People and Fungi

Host Defense® Mushrooms™ was founded by renowned mycologist Paul Stamets with the goal of building a bridge between people and fungi. We specialize in mushroom mycelium-based supplements to support natural immunity and whole body wellness.* Based near the Olympic Rainforest in Washington state, we are one of the best-documented and longest-standing mushroom supplement companies in the USA.

#1 Best Selling Mushroom Supplement Brand in the U.S.

Host Defense® Mushrooms™ began as a direct-to-store manufacturer of mushroom supplements more than 10 years ago. Today, we are the industry leader and the #1 best-selling mushroom supplement brand in the U.S.ꝉ Our continued mission is to explore, study, preserve, and spread knowledge about the use of fungi for helping bees, trees, people, and planet.+
At Host Defense®, all of our product development and formulation is based on scientifically validated data to ensure the quality and efficacy of our supplements. Our mushroom mycelium and fruit bodies are grown on our farm in Washington state and are certified organic, non-GMO, vegan, and gluten-free. And all of our supplements are verified for identity, purity, composition, and strength by independent labs that use internationally recognized, validated testing methods.
Doing the Research
Always at the cutting edge of mycological research, we continuously strive to find new and innovative ways to bridge the divide between human health and beneficial mushrooms. We employ internal teams of mycologists and medical professionals, biologists and chemists, and researchers and educators. Conveniently offering multiple delivery methods – capsules, extracts, sprays, powders, teas, syrups and more! – is one way we work to increase accessibility to the immune-supporting benefits of mushroom mycelium-based supplements.*
Following the Science
One of the most significant outcomes of our research has been discovering the value of using mushroom mycelium. Mycelium is the longest living part of the mushroom organism and consists of highly active cells that serve many important functions - including acting as the immune response of the fungal organism. Years of industry-based research, along with both internal and third-party testing, demonstrates that mycelium-based mushroom supplements offer significant immunological support. That’s why we use mushroom mycelium in ALL of our supplements – because it works!*
Caption: Paul Stamets kneeling in a forest.

Founded by Paul Stamets

Having recognized the enormous potential for the use of beneficial mushrooms and, specifically, mushroom mycelium to support the health of both people and planet, Paul Stamets started Fungi Perfecti® in 1980 with the goal of bridging the divide between people and fungi. Since that time, Paul has become a world-renowned expert in all things mycological.

His central premise is that mushrooms are vital to a healthy immune response in both people and habitats. Just like people, habitats have immune systems. And immune systems become weakened due to stress, disease, and exhaustion. Mushrooms are the cellular bridges to a healthy ecosystem in the habitats where they grow, and—when harnessed in the form of supplements—to support human health.

Caption: Paul Stamets in a Fungi Perfecti lab coat.

Writer, Speaker, Medical Researcher, and Innovator

Paul is considered an industry leader in fungi production, habitat, and medicinal use. He lectures extensively to deepen the understanding and respect for the fungal organisms that literally exist under every footstep taken on this path of life.

The visionary leadership of Paul Stamets has led to significant breakthroughs revealing the power and potential of beneficial mushrooms and, importantly, mushroom mycelium. Some of the research by Paul and his team have led to innovative mycological solutions, including the endless potential for the use of fungi in everything from water filtration (mycofiltration) and ecological rehabilitation (mycoremediation), and to harnessing the power of beneficial mushroom mycelium in the form of supplements to support human and planetary health. Notably, he has partnered with the Department of Entomology at Washington State University to use mushroom mycelium-based extracts to help combat Colony Collapse Disorder in bee populations.

40+ Years of Mycology

As the Founder, Member, Owner at Fungi Perfecti, LLC, he has discovered and named numerous new species of mushrooms and spearheaded numerous research initiatives for the use of fungi. Paul has dedicated his life to discovering, understanding, and spreading knowledge about the unique, mysterious, and fantastic world of fungi.

Land Acknowledgement

Fungi Perfecti acknowledges that our facilities are located on the traditional lands of the Squaxin Island Tribe and the Nisqually Indian Tribe. We recognize and honor the Squaxin and Nisqually people and their ancestors who have stewarded these lands since time immemorial. We express our respect for their sovereignty, their connection to the land, and their contributions to the rich ecological knowledge that guides us today. In the spirit of gratitude and partnership, we commit to working towards a future that upholds Indigenous rights and honors the land we are privileged to share.
*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.

ꝉ Source: SPINSscan Natural / Natural Products Supermarkets > $2MM / Total US - Natural Channel / Mushrooms Ingredient Report / 52 Wks Ending 12/29/2024

+ Your purchase of Host Defense® Mushrooms™ products helps support their mission to reduce carbon emissions, and also supports research to protect bees from colony collapse and conservation of rare mushroom species in old growth forests.
Bridging Science and Innovation with Nature's Wisdom

Featured In

TED: Ideas Worth Spreading
Host Defense is built on Paul Stamets' visionary research into the power and potential of mushrooms, especially mushroom mycelium, the root-like structures found growing below ground. The power of Host Defense comes from the discovery that the mycelium is the immune system of the mushroom.


Just as mycelium helps to support the immune system of humans, it also supports the health and immunity of the natural habitats where it grows. Mushroom mycelium is a cellular bridge connecting bees, trees, bears, plants and humans to the ecosystems in which they live. Our work is to build a healthier world with the power of mushrooms.

Our Global Mission

COLLABORATE
with doctors to help support immunity and health.
PROTECT
the natural environment and all its inhabitants.
PIONEER
strategies to save the honey bee using mushrooms and fungi.
EDUCATE
communities about growing mushrooms for food.
DEVELOP
filtration methods to clean water using mushroom mycelium.
AID
agriculture and forest health by building soil with beneficial fungi.
INVEST
in integrated mushroom technologies to break down or neutralize toxic wastes.
REPLACE
toxic pesticides with natural, non-toxic, non-invasive mushroom-based solutions.
ENCOURAGE
research to develop new biofuels using fungi.
Paul Stamets with an Amadou mushroom
About Paul Stamets, Founder of Host Defense
Paul Stamets, speaker, author, mycologist, medical researcher and entrepreneur, is considered an intellectual and industry leader in fungi: habitat, medicinal use, and production. He lectures extensively to deepen the understanding and respect for the organisms that literally exist under every footstep taken on this path of life. His presentations cover a range of mushroom species and research showing how mushrooms can help the health of people and planet. His central premise is that habitats have immune systems, just like people, and mushrooms are cellular bridges between the two. Our close evolutionary relationship to fungi can be the basis for novel pairings in the microbiome that lead to greater sustainability and immune enhancement.

Paul’s philosophy is that “MycoDiversity is BioSecurity.” He sees the ancient Old Growth forests of the Pacific Northwest as a resource of incalculable value, especially in terms of its fungal genome. A dedicated hiker and explorer, his passion is to preserve and protect as many ancestral strains of mushrooms as possible from these pristine woodlands. His research is considered breakthrough by thought leaders for creating a paradigm shift for helping ecosystems worldwide.
Paul is the author of six books (including Mycelium Running: How Mushrooms Can Help Save The World, Growing Gourmet and Medicinal Mushrooms, and Psilocybin Mushrooms of the World), he has discovered and named numerous new species of psilocybin mushrooms, and is the founder and owner of Fungi Perfecti, LLC, makers of the Host Defense Mushrooms supplement line.
Paul Stamets and C. Dusty Yao
He has received numerous awards, including: Invention Ambassador (2014-2015) for the American Association for the Advancement of Science (AAAS), the National Mycologist Award (2014) from the North American Mycological Association (NAMA), and the Gordon & Tina Wasson Award (2015) from the Mycological Society of America (MSA). His work has entered into the mainstream of popular culture. In the new Star Trek: Discovery series on CBS, the Science Officer is portrayed by an Astromycologist.... a Lt. Paul Stamets. Paul's work with mycelium is a central theme of this series.

Paul funds research to save rare strains of mushrooms that dwell within the old growth forests. He is a collaborator with numerous scientific organizations and research institutes. Currently he is testing extracts of these rare strains at the NIH (National Institutes of Health/Virology) and with Washington State University/United States Department of Agriculture against a wide panel of viruses pathogenic to humans, animals and bees.

“We are now fully engaged in the sixth Major Extinction (“6 X”) on planet Earth. Our biosphere is quickly changing, eroding the life support systems that have allowed humans to ascend. Unless we put into action policies and technologies that can cause a course correction in the very near future, species diversity will continue to plummet, with humans not only being the primary cause, but one of the victims. What can we do? Fungi, particularly mushrooms, offer some powerful, practical solutions, which can be put into practice now.”

Host Defense Mushrooms

A Product of Fungi Perfecti

Building a Bridge Between People and Fungi

Host Defense® Mushrooms™ was founded by renowned mycologist Paul Stamets with the goal of building a bridge between people and fungi. We specialize in mushroom mycelium-based supplements to support natural immunity and whole body wellness.* Based near the Olympic Rainforest in Washington state, we are one of the best-documented and longest-standing mushroom supplement companies in the USA.

#1 Best Selling Mushroom Supplement Brand in the U.S.

Host Defense® Mushrooms™ began as a direct-to-store manufacturer of mushroom supplements more than 10 years ago. Today, we are the industry leader and the #1 best-selling mushroom supplement brand in the U.S.ꝉ Our continued mission is to explore, study, preserve, and spread knowledge about the use of fungi for helping bees, trees, people, and planet.+

Premium Mycelium-Based Mushroom Supplements

At Host Defense®, all of our product development and formulation is based on scientifically validated data to ensure the quality and efficacy of our supplements. Our mushroom mycelium and fruit bodies are grown on our farm in Washington state and are certified organic, non-GMO, vegan, and gluten-free. And all of our supplements are verified for identity, purity, composition, and strength by independent labs that use internationally recognized, validated testing methods.
Doing the Research
Always at the cutting edge of mycological research, we continuously strive to find new and innovative ways to bridge the divide between human health and beneficial mushrooms. We employ internal teams of mycologists and medical professionals, biologists and chemists, and researchers and educators. Conveniently offering multiple delivery methods – capsules, extracts, sprays, powders, teas, syrups and more! – is one way we work to increase accessibility to the immune-supporting benefits of mushroom mycelium-based supplements.*
Following the Science
One of the most significant outcomes of our research has been discovering the value of using mushroom mycelium. Mycelium is the longest living part of the mushroom organism and consists of highly active cells that serve many important functions - including acting as the immune response of the fungal organism. Years of industry-based research, along with both internal and third-party testing, demonstrates that mycelium-based mushroom supplements offer significant immunological support. That’s why we use mushroom mycelium in ALL of our supplements – because it works!*

Founded by Paul Stamets

Having recognized the enormous potential for the use of beneficial mushrooms and, specifically, mushroom mycelium to support the health of both people and planet, Paul Stamets started Fungi Perfecti® in 1980 with the goal of bridging the divide between people and fungi. Since that time, Paul has become a world-renowned expert in all things mycological.

His central premise is that mushrooms are vital to a healthy immune response in both people and habitats. Just like people, habitats have immune systems. And immune systems become weakened due to stress, disease, and exhaustion. Mushrooms are the cellular bridges to a healthy ecosystem in the habitats where they grow, and—when harnessed in the form of supplements—to support human health.

Writer, Speaker, Medical Researcher, and Innovator

Paul is considered an industry leader in fungi production, habitat, and medicinal use. He lectures extensively to deepen the understanding and respect for the fungal organisms that literally exist under every footstep taken on this path of life.

The visionary leadership of Paul Stamets has led to significant breakthroughs revealing the power and potential of beneficial mushrooms and, importantly, mushroom mycelium. Some of the research by Paul and his team have led to innovative mycological solutions, including the endless potential for the use of fungi in everything from water filtration (mycofiltration) and ecological rehabilitation (mycoremediation), and to harnessing the power of beneficial mushroom mycelium in the form of supplements to support human and planetary health. Notably, he has partnered with the Department of Entomology at Washington State University to use mushroom mycelium-based extracts to help combat Colony Collapse Disorder in bee populations.
Photo Credit: Trav Williams, Broken Banjo Photography

40+ Years of Mycology

As the founder and Chief Science Officer at Fungi Perfecti, he has discovered and named numerous new species of mushrooms and spearheaded numerous research initiatives for the use of fungi. Paul has dedicated his life to discovering, understanding, and spreading knowledge about the unique, mysterious, and fantastic world of fungi.
Host Defense® Mushrooms™ are Powered by Mushroom Mycelium™
*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.

ꝉ Source: SPINS scan Natural / Natural Products Supermarkets > $2MM /Total US – Natural Channel / Mushrooms Ingredient Report / 52 Wks 12/29/2020

+ Your purchase of Host Defense® Mushrooms™ products helps support their mission to reduce carbon emissions, and also supports research to protect bees from colony collapse and conservation of rare mushroom species in old growth forests.

Bridging Science and Innovation with Nature's Wisdom

Featured In

TED: Ideas Worth Spreading
Host Defense is built on Paul Stamets' visionary research into the power and potential of mushrooms, especially mushroom mycelium, the root-like structures found growing below ground. The power of Host Defense comes from the discovery that the mycelium is the immune system of the mushroom.


Just as mycelium helps to support the immune system of humans, it also supports the health and immunity of the natural habitats where it grows. Mushroom mycelium is a cellular bridge connecting bees, trees, bears, plants and humans to the ecosystems in which they live. Our work is to build a healthier world with the power of mushrooms.

Our Global Mission

COLLABORATE
with doctors to help support immunity and health.
PROTECT
the natural environment and all its inhabitants.
PIONEER
strategies to save the honey bee using mushrooms and fungi.
EDUCATE
communities about growing mushrooms for food.
DEVELOP
filtration methods to clean water using mushroom mycelium.
AID
agriculture and forest health by building soil with beneficial fungi.
INVEST
in integrated mushroom technologies to break down or neutralize toxic wastes.
REPLACE
toxic pesticides with natural, non-toxic, non-invasive mushroom-based solutions.
ENCOURAGE
research to develop new biofuels using fungi.
Paul Stamets with an Amadou mushroom
About Paul Stamets, Founder of Host Defense
Paul Stamets, speaker, author, mycologist, medical researcher and entrepreneur, is considered an intellectual and industry leader in fungi: habitat, medicinal use, and production. He lectures extensively to deepen the understanding and respect for the organisms that literally exist under every footstep taken on this path of life. His presentations cover a range of mushroom species and research showing how mushrooms can help the health of people and planet. His central premise is that habitats have immune systems, just like people, and mushrooms are cellular bridges between the two. Our close evolutionary relationship to fungi can be the basis for novel pairings in the microbiome that lead to greater sustainability and immune enhancement.

Paul’s philosophy is that “MycoDiversity is BioSecurity.” He sees the ancient Old Growth forests of the Pacific Northwest as a resource of incalculable value, especially in terms of its fungal genome. A dedicated hiker and explorer, his passion is to preserve and protect as many ancestral strains of mushrooms as possible from these pristine woodlands. His research is considered breakthrough by thought leaders for creating a paradigm shift for helping ecosystems worldwide.
Paul is the author of six books (including Mycelium Running: How Mushrooms Can Help Save The World, Growing Gourmet and Medicinal Mushrooms, and Psilocybin Mushrooms of the World), he has discovered and named numerous new species of psilocybin mushrooms, and is the founder and owner of Fungi Perfecti, LLC, makers of the Host Defense Mushrooms supplement line.
Paul Stamets and C. Dusty Yao
He has received numerous awards, including: Invention Ambassador (2014-2015) for the American Association for the Advancement of Science (AAAS), the National Mycologist Award (2014) from the North American Mycological Association (NAMA), and the Gordon & Tina Wasson Award (2015) from the Mycological Society of America (MSA). His work has entered into the mainstream of popular culture. In the new Star Trek: Discovery series on CBS, the Science Officer is portrayed by an Astromycologist.... a Lt. Paul Stamets. Paul's work with mycelium is a central theme of this series.

Paul funds research to save rare strains of mushrooms that dwell within the old growth forests. He is a collaborator with numerous scientific organizations and research institutes. Currently he is testing extracts of these rare strains at the NIH (National Institutes of Health/Virology) and with Washington State University/United States Department of Agriculture against a wide panel of viruses pathogenic to humans, animals and bees.

“We are now fully engaged in the sixth Major Extinction (“6 X”) on planet Earth. Our biosphere is quickly changing, eroding the life support systems that have allowed humans to ascend. Unless we put into action policies and technologies that can cause a course correction in the very near future, species diversity will continue to plummet, with humans not only being the primary cause, but one of the victims. What can we do? Fungi, particularly mushrooms, offer some powerful, practical solutions, which can be put into practice now.”

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*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

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