Best Supplements for Travel: Support for Jet Lag, Digestion, Sleep & Immune Health*

We often hear from customers how much they rely on Host Defense® supplements to support staying healthy for long flights and vacation getaways. Many of these supplements have become a trusted part of their packing list, supporting travel needs related to immune health, stress, digestion, and restful sleep.*
Traveling can bring exciting new experiences, but it can also bring unwanted complications. For instance, according to the CDC, occasional digestive issues affect up to 70% of travelers during trips of two weeks or less.*
“Anytime I’m traveling or in crowds of people I use this.”— Darla J
Moreover, the CDC Yellow Book reports that 68% of international business travelers regularly experience jet-lag symptoms like sleep disturbances and daytime fatigue.
So, while you pack your luggage for your next trip, don’t forget to make some room for the extra “baggage” that can come with traveling. Jet lag, digestive shifts, disrupted sleep, stress, or even strain on your immune system can all get in the way. Being prepared with the right supplements can make a big difference.
From calming your nerves before takeoff to resting easier after landing, Host Defense® supplements can help you stay steady and grounded—even at 35,000 feet.*

Quick Summary
This guide explores a wide variety of supplements to support travel wellness. You’ll learn which mushrooms, herbs, vitamins, and minerals can help your body adapt to common challenges on the road, along with the Host Defense formulas that feature these ingredients to keep you supported on your next trip.*
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Immune support for traveling – How ingredients like Reishi, Chaga, and Turkey Tail help keep your body’s defenses engaged.*
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Digestive health on the go – The role of prebiotics, probiotics, and gut-friendly herbs in helping to maintain a balanced gut and healthy digestion.*
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Better rest away from home – Melatonin-free options like L-Theanine, GABA, and Reishi to support sleep without next-day grogginess.*
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Steady energy and focus – Mushrooms and herbs that promote alertness and mental stamina without side effects such as caffeine crashes.*
Can You Bring Supplements on a Plane? (Rules for Carry-on & Checked Bags)
Before we dive into the best travel supplements to take with you, let’s cover a few common questions about flying with supplements. If you’re bringing any wellness items, whether in a carry-on or checked bag, it helps to know the rules.
(Note: The following tips apply to domestic U.S. travel. If you're flying abroad, always check your destination country’s specific regulations on supplements and herbal products.)
Can you bring supplements on a flight? Yes — absolutely. You can fly with vitamins and supplements in both your carry-on and checked bags. However, there are a few specifics to be aware of when flying:
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Capsules, powders, and tablets: These can go in your carry-on or checked luggage. If you’re bringing more than 12 oz (about 350 mL) of powder, TSA may ask you to remove it from your bag for separate screening.
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Liquids and sprays: These follow the standard 3-1-1 rule. For carry-ons, you can bring liquids in containers no larger than 3.4 oz (100 mL), and all containers must fit inside 1 quart-sized, clear, resealable bag, with 1 bag allowed per passenger.
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Labeling: While not required, keeping your supplements in their original containers can help avoid confusion at security.
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Smart tip: Pack your daily essentials in your carry-on—just in case your checked bag takes the scenic route.

What are the Best Supplements for Travel? (Immune, Digestion, Sleep & more)*
We may not all agree on the perfect vacation destination, but most of us can agree that flying and long-distance travel come with their fair share of challenges. Changing time zones can throw off your body’s internal rhythm, while stressful airport routines, cramped quarters, and unpredictable schedules can leave you feeling drained.
The chart below highlights common travel-wellness challenges and the mushrooms, herbs, vitamins, and minerals that can help. You’ll also see which Host Defense products contain these ingredients to support your needs while traveling. We’ll explore these concepts in greater detail throughout the rest of this article*
Travel Supplement Chart
Travel Challenges | Common Causes | Host Defense Formula That Help* | Key Ingredients |
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Sleep disruption & jet lag* | Time-zone shifts, red-eye flights | MycoBenefits™ Sleep* | Reishi, Lion’s Mane, GABA, L-Theanine, Magnesium Bis-Glycinate, Passionflower, Vitamin B6, Holy Basil |
Brain fog / low focus & mental energy | Sleep loss, fatigue, overstimulation | MycoBenefits™ Focus* | Lion’s Mane, Reishi, Cordyceps, B-Vitamins, Choline, L-Taurine |
Occasional digestive discomfort* | Dehydration, new foods, disrupted routines, hygiene shifts, stress | MycoBotanicals® Microbiome* | Turkey Tail, Reishi, Chicory Root (prebiotic synergy) |
Occasional emotional stress / unease* | TSA, airports, unfamiliarity | MycoBenefits™ Mood* | Reishi, Lion’s Mane, Ashwagandha, L-Theanine, Holy Basil, 5-HTP |
Immune & general wellness* | Airplanes, crowds, changing climates | MycoBotanicals® Immune* | Reishi, Chaga, Maitake, Turkey Tail, Agarikon, Astragalus, Oregano Leaf, Acerola Cherry (Vitamin C), Selenium |
On-the-go format convenience | Travel constraints, minimal space | MycoShield® Spray (TSA-friendly) | Agarikon, Reishi, Chaga, Birch Polypore, Turkey Tail |
How Does Travel Affect Your Immune System?
Research shows that stress and sleep loss can raise cortisol levels and reduce immune responsiveness. Other demands— like crowded airports, recycled cabin air, and exposure to new environments— can make the immune system more vulnerable in transit. Below are some of the most common factors that can challenge immune function while traveling.
Common immunity challenges while traveling:
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Extended travel days, overnight flights, and disrupted sleep cycles, which can weaken immune response and make recovery slower
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Close contact in shared spaces and recycled cabin air, heightening environmental exposures
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Changing climates that require quick adaptation from your immune system
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Dehydration, which can impact the body’s ability to filter and flush out unwanted elements
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Nutritional gaps from irregular meals or limited food options, which may leave the body with fewer resources to support immune function.
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Stress from delays, cancellations, or travel anxiety, which can elevate cortisol and weaken immune responsiveness.
Which Supplements Support Immune Health When Traveling?
MycoBotanicals® Immune*

MycoBotanicals® Immune* combines organic mushroom mycelium from five species with botanicals and vitamin C support to boost and maintain optimal immune function.*
This supplement includes mushrooms like Agarikon, Chaga, and Reishi, which offer beneficial compounds and antioxidants like vitamin C that help maintain a balanced immune response.*
It also includes Turkey Tail, which helps promote beneficial bacteria in the gut. These microbes produce short-chain metabolites that support the integrity of the gut barrier—an important factor since gut health is closely tied to immune function.*
Lastly, Astragalus helps maintain upper-respiratory health, while Acerola Cherry provides a natural source of vitamin C for an extra boost when navigating crowded airports, long flights, and shifting climates.*
Ingredients in MycoBotanicals® Immune*:
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Agarikon
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Chaga
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Turkey Tail
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Reishi
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Maitake
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Acerola Cherry
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Astragalus
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Schizandra
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Goji
MycoShield® Throat Spray

If you want to pack light, MycoShield® Throat Spray is the way to go. It comes in 0.5–2 oz bottles, ideal for your carry-on and the 3-1-1 rule. A few sprays deliver concentrated mushroom extracts for a great way to support immune function.*
It's a blend of five mushroom extracts: Agarikon, Birch Polypore, Reishi, Chaga, and Turkey Tail—prepared using a double and triple extraction method to capture a wide range of beneficial compounds.*
Agarikon and Birch Polypore have a history of traditional use for supporting respiratory wellness, in part by offering compounds that interact with the body’s immune pathways. Then, there’s Turkey Tail, which contributes prebiotic fibers that feed the beneficial gut bacteria—an important part of overall immune function when your routine and diet change during trips.*
Ingredients in MycoShield® Throat Spray:
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Agarikon
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Reishi
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Birch Polypore
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Chaga
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Turkey Tail
Common Challenges with Digestion, Gut Health & Traveling*
Unfamiliar foods, meal timing, new water sources, and even added stress while traveling can all disrupt the balance of microflora in your digestive tract.
Your gut microbiome is a living ecosystem that plays a key role in digestion, nutrient absorption, and overall well-being. Trillions of microbes work together within your gastrointestinal tract, helping you process meals, maintain regularity, and keep your digestive system running smoothly.*

A healthy gut helps regulate immune activity and maintain the gut lining, both important for staying well when your body is adjusting to new foods, water, and environments.*
Common digestive issues when traveling:
Disruptions to this inner ecosystem can bring on occasional challenges, including:
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Bloating, constipation, or irregular stools
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General discomfort or sluggish digestion
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Imbalances in gut flora
What causes digestive issues in-flight or during travel?
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Sudden changes to your eating and sleep routine
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Indulging in unfamiliar foods
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Dehydration from dry cabin air or climate
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Emotional stress or anxiety, which can impact digestion through the gut-brain axis
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Disrupted eating routines and irregular meal timing
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Lack of movement during long travel stretches
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Exposure to new microflora in different regions
Supplements for Supporting Digestion and Microbiome When Traveling*
MycoBotanicals® Microbiome* Powder

MycoBotanicals® Microbiome* blends three prebiotic mushrooms with herbs and probiotics to support gut microbiome, encourage microbial diversity, and promote daily digestive health.*
Prebiotics are non-digestible fibers and compounds that feed the beneficial bacteria already in your gut, helping them thrive and maintain balance. On the other hand, probiotics are microorganisms that can compliment this ecosystem.*
This formula pairs prebiotic mushrooms like Turkey Tail, Lion’s Mane, and Reishi, with herbal prebiotics such as Marshmallow Root and Burdock Root. These ingredients not only feed beneficial gut flora but also help maintain the protective mucosal lining of the digestive tract.*
To round out this support, Microbiome* includes a blend of spore-forming probiotics. These strains are designed to complement prebiotics, aiding healthy microbial balance and steady digestion.*
Ingredients in MycoBotanicals® Microbiome*:
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Turkey Tail
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Lion’s Mane
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Reishi
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Marshmallow Root
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Burdock Root
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Probiotic Blend
Experiencing Jet Lag & Sleep Disruption
Jet lag is practically synonymous with long-distance travel. When you fly across time zones, your body’s internal clock (also known as the circadian rhythm) gets out of sync with local time.
As a result, you could be stuck wide awake at 3 AM, only to find yourself later nodding off midafternoon. Even on domestic trips or red-eye flights, skipping a few hours of rest can leave you feeling disoriented and drained.

What jet lag feels like: It’s more than just feeling tired. Jet lag can bring on headaches, irritability, daytime fatigue, digestive unease, and that strong sense of brain fog. Essentially, your body is saying it’s time to sleep while your surroundings show completely opposite signs of sunlight and bustling streets.
How long does it take to adjust? Your body typically needs about one day per time zone crossed to fully reset its sleep-wake cycle. Meaning if you were to cross five time zones, like on a trip from New York to London, it could potentially take up to five days to adapt.
Some studies suggest even deeper circadian processes can take 8–10 days to realign.
Supplement for Sleep Support While Traveling
MycoBenefits™ Sleep*

When jet lag and restless hotel nights won’t seem to let up, MycoBenefits™ Sleep* offers a melatonin-free way to ease into rest. This formula combines calming mushroom mycelium with carefully selected compounds that support relaxation without leaving you groggy the next day.*
Sleep* contains Reishi, an adaptogenic mushroom, which helps aid the body’s stress response. When travel stress spikes cortisol and makes it harder to unwind, Reishi encourages a smoother transition into rest by supporting a calmer mind and body.*
To quiet a busy mind, GABA works on calming neural pathways, while L-theanine promotes brain wave patterns linked with relaxed focus. Together, they create the conditions to drift off more naturally rather than forcing heavy sedation.*
To top it all off, Magnesium bis-glycinate (a highly absorbable form) can promote muscle relaxation, while vitamin B6 works to support your natural sleep-wake rhythm.*
Ingredients in MycoBenefits™ Sleep*:
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Reishi
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Lion’s Mane
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GABA
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L-Theanine
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Magnesium bis-glycinate
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Passionflower
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Vitamin B6
Stress Support While Traveling*
Planning a getaway to unwind and recharge always sounds ideal. That is, until your peaceful escape turns into a series of delays, missed connections, and overcrowded terminals—reminding you just how easily a trip to de-stress can become… quite stressful.