New to supplements?
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Lion's Mane Capsules 
Lion's Mane CapsulesFrom $20.95From $20.95 -
Stamets 7® Capsules 
Stamets 7® CapsulesFrom $20.95From $20.95 -
Turkey Tail Capsules 
Turkey Tail CapsulesFrom $20.95From $20.95 -
MyCommunity® Capsules 
MyCommunity® CapsulesFrom $20.95From $20.95 -
Host Defense® Lion’s Mane Gummies 
Host Defense® Lion’s Mane Gummies$34.95$34.95 -
Host Defense® Immune* Gummies 
Host Defense® Immune* Gummies$34.95$34.95 -
Grateful Dead Gummies™ - Cosmic Focus™* 
Grateful Dead Gummies™ - Cosmic Focus™*$36.95$36.95 -
Grateful Dead Gummies™ - Stay Mellow™* 
Grateful Dead Gummies™ - Stay Mellow™*$36.95$36.95 -
Grateful Dead Gummies™ - Beary Well™* 
Grateful Dead Gummies™ - Beary Well™*$36.95$36.95 -
Lion's Mane Extract 
Lion's Mane ExtractFrom $20.95From $20.95 -
MycoBotanicals® Brain* Capsules 
MycoBotanicals® Brain* Capsules$31.95$31.95 -
Lion's Mane Powder 
Lion's Mane PowderFrom $31.95From $31.95 -
Reishi Capsules 
Reishi CapsulesFrom $20.95From $20.95 -
MycoBenefits® Peri Meno* 
MycoBenefits® Peri Meno*$29.95$29.95 -
MycoBenefits® PMS* 
MycoBenefits® PMS*$29.95$29.95 -
MycoBenefits® Sleep* Capsules 
MycoBenefits® Sleep* Capsules$29.95$29.95
Welcome to Host Defense Mushrooms! Founded by Paul Stamets, our mushroom mycelium and fruit bodies grown on our certified organic farm in Washington State are non-GMO, vegan, and gluten-free. We base our formulations on scientifically proven data to ensure quality and safety, which is why we are the best selling mushroom supplement brand in the U.S.ꝉ
A product of Fungi Perfecti, LLC. Building Better Health Since 1980.*
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All Host Defense® products
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Lion's Mane Capsules
Lion's Mane CapsulesFrom $20.95From $20.95 -
Stamets 7® Capsules
Stamets 7® CapsulesFrom $20.95From $20.95 -
Turkey Tail Capsules
Turkey Tail CapsulesFrom $20.95From $20.95 -
MyCommunity® Capsules
MyCommunity® CapsulesFrom $20.95From $20.95 -
Lion's Mane Powder
Lion's Mane PowderFrom $31.95From $31.95 -
Grateful Dead Gummies™ - Cosmic Focus™*
Grateful Dead Gummies™ - Cosmic Focus™*$36.95$36.95 -
Grateful Dead Gummies™ - Stay Mellow™*
Grateful Dead Gummies™ - Stay Mellow™*$36.95$36.95 -
Grateful Dead Gummies™ - Beary Well™*
Grateful Dead Gummies™ - Beary Well™*$36.95$36.95 -
Host Defense® Lion’s Mane Gummies
Host Defense® Lion’s Mane Gummies$34.95$34.95 -
Host Defense® Immune* Gummies
Host Defense® Immune* Gummies$34.95$34.95 -
MycoBenefits® Peri Meno*
MycoBenefits® Peri Meno*$29.95$29.95 -
MycoBenefits® PMS*
MycoBenefits® PMS*$29.95$29.95 -
Stamets 7® Powder 
Stamets 7® PowderFrom $31.95From $31.95 -
MycoBenefits® Focus* Capsules 
MycoBenefits® Focus* Capsules$29.95$29.95 -
MycoBenefits® Beauty Capsules 
MycoBenefits® Beauty Capsules$29.95$29.95 -
MycoBenefits® Mood* Capsules 
MycoBenefits® Mood* Capsules$29.95$29.95 -
MycoBenefits® Sleep* Capsules
MycoBenefits® Sleep* Capsules$29.95$29.95 -
Reishi Capsules
Reishi CapsulesFrom $20.95From $20.95 -
Cordyceps Capsules 
Cordyceps CapsulesFrom $20.95From $20.95 -
Agarikon Capsules 
Agarikon CapsulesFrom $36.95From $36.95 -
Cordyceps Powder 
Cordyceps Powder$31.95$31.95 -
Turkey Tail Powder 
Turkey Tail PowderFrom $31.95From $31.95 -
Lion's Mane Extract
Lion's Mane ExtractFrom $20.95From $20.95 -
Turkey Tail Extract 
Turkey Tail ExtractFrom $20.95From $20.95
What People are Saying
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"Taking this has improved my mood and my sleep. I also feel calmer. Thank you."
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"The subscribe and save is great, I receive a heads up before shipping. This is a legit company to support."
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"Using this primarily for cardiovascular support but there is beneficial calming /centering qualities enjoyed here as well."
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"The product is outstanding it's a lot better than I expected I'm remembering things that I had forgotten a long time ago."
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"Cordyceps definitely boosted my energy, in a way that was healthy and not like the boost from caffeine."
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"These gummies are delicious, and I know that they're full of excellent healthy ingredient. Thank you"
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"Great product. It takes the guesswork out of trying to achieve a balanced blend."
